Synthesis of a Substituted Benzazepin-2-one Dihydrate

[摘要]：Synthesis Of the title Compound was accomplished via Coupling of (S)-alaninyl-(S)-1-amino-3-methyl-4,5,6,7-tetraliydro-2H-3-benzazepin-2 -one with the activated trimethylsilyl ester of (S)-2-trimethylsilyloxy-3-methylbutyric acid, followed by deprotection and crystallization in situ. The starting material was prepared by the condensation of (S)-1-amino-3-methyl-4,5,6,7-tetrahydro-2H-3-benzazepin-2-one with activated N-(2-methoxycarbonyl-1-methylvinyl)-(S)-alanine sodium salt in the form of the mixed carboxylic carbonic anhydride, followed by enamine hydrolysis using methanesulfonic acid.

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