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[摘要]：An improved synthesis of 3-{2-[2-(bromomethyl)tiazol-4-yl]ethynyl}-5-fluorobenzonitrile, a precursor for PET radioligand [F-18]SP203, is described, wherein a new synthon was employed for Sonogashira Coupling with 3-bromo-5-fluorobenzonitrile. The new Five-step synthesis provided the title compound in 56% overall yield starting from 4-bromo-2-formylthiazole. |
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