Facile Synthesis of Fluorinated Benzofuro- and Benzothieno[2,3-b]pyridines, alpha-Carbolines and Nucleosides Containing the alpha-Carboline Framework

[摘要]：Fluorinated benzofuro[2,3-b]pyridines, benzothieno[2,3-b] pyridines and 9H-pyrido[2,3-b]indoles (alpha-carbolines) were synthesized via regiospecific pyridine core annulation of a number of fluoro-containing 1,3-CCC-dielectrophiles to benzofuran-2-amine, benzothiophen-2-amine and 1H-indol-2-amine. Based on the 2,4-bis(trifluoromethyl)-9H-pyrido[2,3-b]indole thus synthesized, the preparative approach towards a set of nucleosides and nucleoside mimetics bearing the alpha-carboline framework was elaborated.

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