Efficient Fluoride-Mediated Synthesis of 5-Amino-Substituted Isothiazoles
[摘要]:Fluoride-mediated nucleophilic substitution reactions of teri-butyl 4,5-dichloroisothiazole-3-carboxylate with various amines occur under mild conditions yielding 5-(alkylamino)isothiazoles in moderate to high yields.
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