TRUNCATED ASPIDOSPERMA ALKALOID-LIKE SCAFFOLDS: UNIQUE STRUCTURES FOR THE DISCOVERY OF NEW, BIOACTIVE COMPOUNDS

[摘要]：Exploration into the dienophilicity of indole in inverse electron demand Diels-Alder reactions has led to the development of the triazatetracyclo[7.7.0.0(1,13).0(2,7)]hexadeca-2,4,6,10,12-pentaene and related scaffolds for diversification in the search for new, biologically active compounds. The libraries constructed from these core structures have lead to the discovery of new anti-viral and anti-malarial compounds.

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