Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography

[摘要]：Here we report the total synthesis of kaliotoxin by 'one pot' native chemical ligation of three synthetic peptides. A racemic mixture of D- and L-kaliotoxin synthetic protein molecules gave crystals in the centrosymmetric space group P1 that diffracted to atomic-resolution (0.95 angstrom), enabling the X-ray structure of kaliotoxin to be determined by direct methods.

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