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The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties

作者	Imbriglio, JE; DiRocco, D; Bodner, R; Raghavan, S; Chen, WC; Marley, D; Esser, C; Holt, TG; Wolff, MS; Taggart, AKP; Waters, MG; Tata, JR; Colletti, SL

选自	期刊 Bioorganic & Medicinal Chemistry Letters; 卷期 2011年21-9; 页码 2721-2724

关联知识点

[摘要]：Amino-anthranilic acid derivatives have been identified as a new class of low serum shifted, high affinity full agonists of the human orphan G-protein-coupled receptor GPR109a with improved ADME properties. (C) 2010 Elsevier Ltd. All rights reserved.
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