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[摘要]：Two new chromanone derivatives, tabchromones A and B (1-2), together with four known compunds (3-6) were isolated from the roots and stems of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D- NMR techniques. Compounds 1-6 were tested for their in vitro cytotoxicity against five human tumor (NB4, A549, SHSY5Y, PC3, and MCF7) cell lines. Compound 1 showed significant inhibitory effect against SHSY5Y cell line, with 1050 values of 2.8 mu M, and compounds 2-4 showed moderate activity for some selected cell lines, with IC50 values in the range of 4.8-8.0 mu M. |
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