【文章名】A Synthesis of N-Bridged 5,6-Bicyclic Pyridines via A Mild Cyclodehydration Using the Burgess Reagent and Discovery of A Novel Carbamylsulfonylation Reaction.
A Synthesis of N-Bridged 5,6-Bicyclic Pyridines via A Mild Cyclodehydration Using the Burgess Reagent and Discovery of A Novel Carbamylsulfonylation Reaction.
作者
Li, Jie Jack;Li, James J.;Li, Jun;Trehan, Ashok K.;Wong, Henry S.;Krishnananthan, Subramanian;Kennedy, Lawrence J.;Gao, Qi;Ng, Alicia;Robl, Jeffrey A.;Balasubramanian, Balu;Chen, Bang-Chi;
[摘要]：Cyclodehydration using the Burgess reagent provided a novel approach toward the synthesis of N-bridged 5,6-bicyclic pyridines including pyrrolo-, imidazo-, and triazolopyridines, e.g., I, under mild and neutral conditions. The methodol. tolerates acid-sensitive functional groups. A novel addn. product was obsd. between the resulting pyrrolo- or imidazopyridine and an addnl. equiv. of the Burgess reagent, producing the corresponding sulfonylcarbamate adduct, e.g. II.
