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Three-Step Synthesis of 2,4-Diaryl-5,6,7,8-tetrahydroquinoline Derivatives

  作者 GEZEGEN HAYREDDIN; DINGIL ALPARSLAN; CEYLAN MUSTAFA  
  选自 期刊  Journal of Heterocyclic Chemistry;  卷期  2010年47-5;  页码  1017-1024  
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[摘要]Addition of cylohexanone to chalcones, obtained from the appropriate acetophenone and benzaldehyde derivatives, under solvent-free conditions gave 1,5-diketones in good yields. Treatment of 1,5-diketones with ammonium acetate in acetic acid afforded directly 2,4-diaryl-5,6,7,8-tetrahydroquinoline derivatives (7a-u) in high yields. The structures of 7a-u were elucidated by H-1 NMR, C-13 NMR, IR, and elemental analysis.

 
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