Structural analysis of PI3-kinase isoforms: Identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors

[摘要]：A series of small molecule, ATP-competitive phosphoinositide 3-kinase inhibitors have been examined in homology models of the four class 1 isoforms, p110 alpha, p110 beta, p110 delta and p110 gamma. This analysis provided an insight into the mode of binding of these inhibitors to the hinge and to other key regions of the ATP binding site in each of the four subtypes. Significantly, residues were identified that differ between these proteins, and which help explain the isoform selective inhibition profiles of the compounds. (C) 2008 Elsevier Inc. All rights reserved.

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