Uricases as Therapeutic Agents to Treat Refractory Gout: Current States and Future Directions

[摘要]：Treatment of refractory gout remains a challenge on drug development. While pegloticase, a recombinant mammalian uricase modified with monomethoxyl poly(ethylene glycol) (mPEG) is effective in treating refractory gout, after continued treatment for 3 mont

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