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Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases

  作者 Ple, PA; Jung, F; Ashton, S; Hennequin, L; Laine, R; Morgentin, R; Pasquet, G; Taylor, S  
  选自 期刊  Bioorganic & Medicinal Chemistry Letters;  卷期  2012年22-1;  页码  262-266  
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[摘要]A new series of Quinazoline Ether Inhibitor which potently inhibits VEGFR-2 and PDGFR tyrosine kinases is described here. In vitro, pharmacokinetics and in vivo evaluations led to the selection of AZD2932. (C) 2011 Elsevier Ltd. All rights reserved.

 
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