A New Facile Approach to Isoindole and Pyrrole Derivatives

[摘要]：A highly efficient protocol for the synthesis of N-substituted di-/tetrahydroisoindole derivatives and N-substituted pyrroles fused with seven-membered rings has been developed by reaction of amines with 3-(2-formyl-cycloalkenyl) alpha,beta-unsaturated esters or nitriles, which, in turn, were prepared from beta-bromovinyl aldehydes by a Pd(0)-catalyzed Heck reaction. Bisisoindoles were also achieved by this room-temperature procedure.

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