[摘要]:Aldol reactions of racemic enolizable dioxolan-protected alpha-substituted-beta-ketoaldehydes with representative achiral ketones catalyzed by proline or 5-(2-pyrrolidine-2-yl)-1H-tetrazole in wet DMSO proceed with dynamic kinetic resolution (or via DYKAT with an alpha-substituted-beta-alkoxyaldehyde) to give adducts with high dr and ee. |