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Pot, atom, and step economic (PASE) synthesis of highly substituted piperidines: a five-component condensation.

  作者 Clarke, Paul A.;Zaytsev, Andrey V.;Whitwood, Adrian C.;  
  选自 期刊  Synthesis;  卷期  2008年-21;  页码  3530-3532  
  关联知识点  
 

[摘要]The diastereoselective pot, atom, and step economic (PASE) synthesis of highly functionalized piperidines is reported. The procedure simply involves mixing of acetoacetate with 2 equiv arom. aldehyde and 2 equiv aniline together in the presence of InCl3. In most cases the piperidine ppts. out of soln.

 
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