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[摘要]:Access to 3,4-disubstituted N-benzylprolinol derivatives is described that, after optimization of the ring-enlargement reaction conditions, Could be efficiently transformed into the corresponding 3-hydroxypiperidines. This approach was applied to the asymmetric synthesis of (+)-isofagomine relying oil regio- and stereoselective oxirane opening with the cyanide anion of a pivotal epoxypyrrolidine. |
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