【文章名】Matching the Chirality of Monodentate N-Heterocyclic Carbene Ligands: A Case Study on Well-Defined Palladium Complexes for the Asymmetric a-Arylation of Amides.
Matching the Chirality of Monodentate N-Heterocyclic Carbene Ligands: A Case Study on Well-Defined Palladium Complexes for the Asymmetric a-Arylation of Amides.
[摘要]：N-Heterocyclic carbene ligands derived from C2-sym. diamines with naphthyl side chains are introduced as chiral monodentate ligands, and their palladium complexes (NHC)Pd(cin)Cl are prepd. These compds. exist as a mixt. of diastereomers, and the palladium complexes can be successfully sepd. and their abs. stereochem. assigned. When used in the asym. intramol. a-arylation of amides, oxindoles with quaternary carbon centers can be obtained in high yield and selectivity when correctly matching the chirality of the NHC complexes.
