A New Synthesis of Cytotoxic Thiosulfonates and the First Synthesis of Deuterated Thiosulfonates

[摘要]：A new synthesis of thiosulfonates starting from thiophenols and cyanuric chloride activated dimethyl sulfoxide is reported herein. Although the yields of the reactions are moderate, this method enables the incorporation of the SCD(3) group of dimethyl sulfoxide-d(6) into thiosulfonates. This is the first synthesis of deuterated thiosulfonates with a labeling purity above 99%. In addition, the cytotoxicity of the thiosulfonates is reported for the first time.

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