Diastereoselective Multicomponent Reaction in Water: Synthesis of 2-Azapyrrolizidine Alkaloid Analogues

[摘要]：Synthesis of the 2-aza analogues of the pyrrolizidine alkaloid motif with two contiguous stereocenters has been achieved with high regio-, chemo-, and diastereoselectivity by an innovative multicomponent reaction in water. This elegant tactic has integrated the principles of privileged substructure-based Diversity Oriented Synthesis (pDOS) and Biology Oriented Synthesis (BIOS) to access a biologically relevant scaffold.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内