Synthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators

[摘要]：Herein, the synthesis of novel hydrophobic and hydrophilic cobinamides via aminolysis of vitamin B-12 derivatives that activate soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators, they target the catalytic domain of sGC and. show higher activity than (CN)(2)Cbi.

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