| |
[摘要]：A bioassay-guided fractionation of the heartwood of Santalum album led to the isolation of seven alpha-santalol derivatives including (9S,10E)-9-hydroxy-alpha-santalal, (10R,11S)-10,11-dihydroxy-alpha-santalol, (9E)-11,13-dihydroxy-alpha-santalol, and (10E)-12-hydroxy-alpha-santalic acid. Their structures were determined on the basis of results of spectroscopic analysis, including two-dimensional (2D) NMR spectroscopic data. The isolated compounds and derivatives were evaluated for cytotoxicity against HL-60 human promyelocytic leukemia cells and TIG-3 normal human diploid fibroblasts. Of these (9S,10E)-9-hydroxy-alpha-santalal, exhibited tumor-selective cytotoxicity. The apoptosis induction properties of sesquiterpenes with cytotoxic potency in HL-60 cells are also described. (C) 2012 Elsevier Ltd. All rights reserved. |
|
