【文章名】Synthesis and antimicrobial evaluation of novel pyrazolo[1,5-a]pyrimidine, pyrimido[1,2-a]benzimidazole, triazolo[4,3-a]pyrimidine and pyrido[1,2-a]benzimidazole derivatives incorporated phenylsulfonyl moiety.
Synthesis and antimicrobial evaluation of novel pyrazolo[1,5-a]pyrimidine, pyrimido[1,2-a]benzimidazole, triazolo[4,3-a]pyrimidine and pyrido[1,2-a]benzimidazole derivatives incorporated phenylsulfonyl moiety.
[摘要]：PhSO2CH2CN reacts with DMF-DMA to afford 3-(dimethylamino)-2-(phenylsulfonyl)acrylonitrile (I). Subsequent reaction with 5-aminopyrazoles, 5-amino-1,2,4-triazole, and 2-aminobenzimidazole afforded new pyrazolo[1,5-a]pyrimidine, triazolo[4,3-a]pyrimidine, and pyrimido[1,2-a]benzimidazole derivs., resp. Also, I reacts with 1H-benzimidazole-2-acetonitrile to give the corresponding pyrido[1,2-a]benzimidazole. Some of the newly synthesized compds. were tested in vitro for antibacterial and antifungal activity, and showed promising results.
