Synthesis and antimicrobial evaluation of some bis(thioxopyridine), bis(pyrazolo[3,4-b]pyridine), bis(thieno[2,3-b]pyridine), bis(1,3,4-thiadiazole) and bis-thiophene derivatives.

[摘要]：Condensation of (NCCH2CONHCH2)2 with arom. aldehydes gave the corresponding N,N'-(ethane-1,2-diyl)bis(2-cyano-3-phenylacrylamides). The latter products react with NCCH2CSNH2 to afford 1,2-bis(4-aryl-3,5-dicyano-6-mercapto-2-oxo-1,2-dihydropyridin-1-yl)eth anes I (R = H, MeO, Cl). Treatment of I (R = H) or its S-Me deriv. with N2H4.H2O afforded 1,2-bis(3-amino-5-cyano-6,7-dihydro-7-methyl-6-oxo-4-phenyl-1H-pyraz olo[3,4-b]pyridin-1-yl)ethane. Reaction of I (R = MeO) with AcCH2Cl gave 1,2-bis[2-acetyl-3-amino-6,7-dihydro-5-cyano-4-(4-methoxyphenyl)-6-ox othieno[2,3-b]pyridine-7-yl]ethane. Treatment of (NCCH2CONHCH2)2 with PhNCS afforded N,N'-(ethane-1,2-diyl)bis[2-cyano-3-mercapto-3-(phenylamino)acrylami de], which reacts with hydrazonoyl halides or halo ketones to give the corresponding N,N'-(ethane-1,2-diyl)bis[2-cyano-2-(3,5-disubstituted-2(3H)-1,3,4-thiad iazolylidene)acetamides] or N,N'-(ethane-1,2-diyl)bis[4-amino-5-substituted-2-(phenylamino)thiophe ne-3-carboxamides], resp. Antimicrobial evaluation of selected examples of the newly synthesized compds. was carried out.

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