Carotenoids with anti-Helicobacter pylori Activity from Golden Delicious Apple

[摘要]：Previously it was reported that hypophasic carotenoids of Golden delicious apple peel showed potent anti-H. pylori activity (MIC50 = 36 mu g/mL), comparable to metronidazole (MIC50 = 45 mu g/mL). To further investigate the involved active carotenoids of the apple peel extracts, seven carotenoids were isolated for the current study: (all-E)-luteoxanthin, (all-E)-neoxanthin, (9'Z)-neoxanthin, (all-E)-antheraxanthin, (all-E)-violaxanthin, (9Z)violaxanthin and (all-E)-lutein. The MIC50 values of (all-E)-luteoxanthin, (all-E)-neoxanthin and (9'Z)neoxanthin were 7.9, 11 and 27 mu g/mL, respectively. Other carotenoids and beta,beta-carotene did not exhibit potent anti-H. pylori activity (MIC50 > 100 mu g/mL). An examination of structure and function suggested that active carotenoids contained a monofuranoid ring or an allenic bond in addition to an epoxy group and an additional two or three hydroxyl substituents on the side group. Copyright (C) 2009 John Wiley & Sons, Ltd.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内