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[摘要]：Conopeptides are the peptidic components of the venoms of marine cone snails from the Conus genus. Aside from their natural function in pharmacologically immobilizing prey, they have attracted the attention of drug designers in recent years because of their potency and selectivity at a range of pharmaceutically important targets in mammals, including ion channels and neurotransmitter transporters. One conopeptide, MVIIA (ziconotide, Prialt (R)), is on the market for the treatment of intractable neuropathic pain and others are in preclinical or clinical development. This article provides an overview of recent developments in the conopeptide field, with particular reference to their potential applications as drugs for the treatment of pain. |
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