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Nordihydroguaiaretic acid autoxidation produces a schisandrin-like dibenzoeyclooctadiene lignan

  作者 Billinskyt, JL; Krol, ES  
  选自 期刊  Journal of natural products;  卷期  2008年71-9;  页码  1612-1615  
  关联知识点  
 

[摘要]The lignan meso-nordihydroguaiarctic acid is known to undergo spontaneous oxidation in alkaline solution. In the presence of the trapping agent glutathione, the major oxidation products are consistent with the formation of a mesonordihydroguaiaretic acid ortho-quinone. In the absence of a trapping agent however, the major oxidation product of meso-nordihydroguaiaretic acid in aqueous solution is a unique, stable schisandrin-like dibenzocyclooctadiene lignan that may be responsible for some of the biological effects of nordihydroguaiaretic acid.

 
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