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An Expedient Synthesis of 2,4,6-Tris(trifluoromethyl)aniline

  作者 EDELBACH BRIAN L; PHAROAH BLAZE M; BELLOWS SARINA M; THAYER PETER R; FENNIE CHARLES N; COWLEY RYAN E; HOLLAND PATRICK L  
  选自 期刊  Synthesis;  卷期  2012年44-23;  页码  3595-3597  
  关联知识点  
 

[摘要]A simple two-step synthetic route leads to 2,4,6-tris(trifluoromethyl) aniline. It proceeds through deprotonation and iodination of 1,3,5-tris(trifluoromethyl) benzene, followed by copper-catalyzed amination.

 
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