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Preparation of 3-Alkyl-Oxindoles by Copper(II)-Mediated C-H, Ar-H Coupling Followed by Decarboxyalkylation

  作者 PUGH DAVID S; KLEIN JOHANNES E M N; PERRY ALEXIS; TAYLOR RICHARD J K  
  选自 期刊  SYNLETT;  卷期  2010年-6;  页码  934-938  
  关联知识点  
 

[摘要]A novel route for the conversion of anilides into 3-alkyloxindoles is described in which a copper(II)-mediated cyclization process is followed by an acid-mediated decarboxyalkylation. Scope and limitation studies are reported together with a telescoped variant which incorporates in situ N-deprotection.

 
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