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[摘要]：The perylenequinones are a class of natural products characterized by a pentacyclic conjugated chromophore giving rise to photoactivity. Potentially useful light-activated biological activity, targeting protein kinase C (PKC), has been identified for several of the natural products. Recently discovered new members of this compound class, as well as several related phenanthro-perylenequinones, are reviewed. Natural product modifications that improve biological profiles are outlined, as well as avenues for the total synthesis of analogs not available from the natural product series. An overview of structure/function relationships is provided. |
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