Enantioselective Synthesis of SSR 241586 by Using an Organo-Catalyzed Henry Reaction

[摘要]：An organo-catalyzed Henry reaction, applied to an alpha-keto ester, has allowed the enantioselective synthesis of SSR 241586, a 2,2-disubstituted morpholine active in the treatment of schizophrenia and irritable bowel syndrome (IBS).

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