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[摘要]：The natural product aigialomycin D (1) is a member of the resorcylic acid lactone (RAL) family possessing protein kinase inhibitory activities. This paper describes the synthesis of aigialomycin D and a series of its analogues and their activity for the inhibition of protein kinases related to cancer pathways. A preliminary study of these compounds in the inhibition of CDK2/cyclin A kinase has found that aigialomycin D and analogues 11 and 23 are moderate CDK2/cyclin A inhibitors with IC(50) values of ca. 20 mu M. Kinase profiling of aigialomycin D against a panel of kinases has led to the identification of MNK2 as a promising target (IC(50) = 0.45 mu M), and preliminary structure-activity relationship studies have been carried out to identify the essential functional groups for activity. |
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