Synthesis and anti-tumor activities of some new pyridines and pyrazolo [1,5-a]pyrimidines

[摘要]：Cyclocondensation of cyanoacetamide, cyanothioacetamide and 3-aminopyrazols with sodium salt of 3-hydroxy-1-(2-naphthyl)prop-2-en-1-one gives pyridin-2-one, pyridin-2(1H)-thione, and pyrazolo[1,5-a]pyrimidine derivatives. These derivatives showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines. (C) 2009 Elsevier Masson SAS. All rights reserved.

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