A CONVENIENT SYNTHESIS OF 2-ARYLTHIOCHROMEN-4-ONES (THIOFLAVONES) BY IODINE-MEDIATED CYCLIZATION OF 3-ARYL-1-[2-(1,1-DIMETHYLETHYLSULFANYL)PHENYL]PROP-2-EN-1-ONES

[摘要]：A convenient two-step synthesis of 2-arylthiochromen-4-ones (thioflavones) beginning with 1-[2-(1,1-dimethylethylsulfanyl)phenyl]ethanones is described. Thus, 3-aryl-1-[2-(1,1-dimethylethylsulfanyl)phenyl]prop-2-en-1-ones were prepared by the condensation of 1-[2-(1,1-dimethylethylsulfanyl)phenyl]ethanones with aromatic aldehyde in the presence of sodium hydroxide, and were treated with iodine in refluxing N-methylpyrrolidin-2-one (NMP) or propanenitrile to afford the desired products in moderate to fair yields.

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