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Kinetic Resolution of Secondary Alcohols by the Combination of a Chiral Bronsted Acid, DABCO, and Acetyl Chloride

  作者 MANDAI HIROKI; MUROTA KYOUTA; MITSUDO KOICHI; SUGA SEIJI  
  选自 期刊  Organic Letters;  卷期  2012年14-13;  页码  3486-3489  
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[摘要]An efficient and simple protocol for the kinetic resolution of secondary alcohols is presented. The new system is based on a combination of chiral Bronsted acid, DABCO, and acetyl chloride and gives various enantioenriched alcohols with selectivity factors up to 105.

 
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