Diastereoselective Mannich Reaction of Chiral Enolates Formed by Enantioselective Conjugate Addition of Grignard Reagents

[摘要]：CuTaniaphos-catalyzed enantioselective addition of Grignard reagents to cyclic enones leads to chiral magnesium enolates. These enolates add to N-protected imines directly, or through in situ transformation to silyl enol ethers. Diastereoselectivity of the addition depends on the nitrogen protecting group of the imine. Diastereoisomers of the resulting beta-amino carbonyl compounds can be separated and are obtained in acceptable yields and in high enantiomeric purities (up to 99:1?er).

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