Starting from trimethylsilylacetylene, a facile synthesis of optically pure spiroketal unit of (+)-spiroxaline methyl ether has been described. The synthesis entails stepwise alkylation and acylation of an alkyne with tw...
Fluoroalkylsulfonyl azides were successfully employed as an efficient reacting partner in copper(I)-catalyzed three-component couplings with terminal alkynes and amines to afford the corresponding N'-(fluoroalkylsulfonyl...
A series of 3-amino-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-ones and 6-hydroxy-5,6-dihydropyridin-2(1H)-ones were hydrogenated to give the corresponding piperidinones. These lactams were used for the synthesis of no...