- Botulinum Neurotoxin Is Shielded by NTNHA in an Interlocked Complex
[作者：Gu, SY; Rumpel, S; Zhou, J; Strotmeier, J; Bigalke, H; Perry, K; Shoemaker, CB; Rummel, A; Jin, RS,期刊：Science, 页码：977-981 , 文章类型： Article，,卷期：2012年335-6071]
- Botulinum neurotoxins (BoNTs) are highly poisonous substances that are also effective medicines. Accidental BoNT poisoning often occurs through ingestion of Clostridium botulinum-contaminated food. Here, we present the c...
- Evolution of the Earliest Horses Driven by Climate Change in the Paleocene-Eocene Thermal Maximum
[作者：Secord, R; Bloch, JI; Chester, SGB; Boyer, DM; Wood, AR; Wing, SL; Kraus, MJ; McInerney, FA; Krigbaum, J,期刊：Science, 页码：959-962 , 文章类型： Article，,卷期：2012年335-6071]
- Body size plays a critical role in mammalian ecology and physiology. Previous research has shown that many mammals became smaller during the Paleocene-Eocene Thermal Maximum (PETM), but the timing and magnitude of that c...
- Evolutionarily Assembled cis-Regulatory Module at a Human Ciliopathy Locus
[作者：Lee, JH; Silhavy, JL; Lee, JE; Al-Gazali, L; Thomas, S; Davis, EE; Bielas, SL; Hill, KJ;,期刊：Science, 页码：966-969 , 文章类型： Article，,卷期：2012年335-6071]
- Neighboring genes are often coordinately expressed within cis-regulatory modules, but evidence that nonparalogous genes share functions in mammals is lacking. Here, we report that mutation of either TMEM138 or TMEM216 ca...
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