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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共69条记录   New Genes in Drosophila Quickly Become Essential [作者：Chen, SD; Zhang, YE; Long, MY,期刊：Science, 页码：1682-1685 , 文章类型： Article，,卷期：2010年330-6011] To investigate the origin and evolution of essential genes, we identified and phenotyped 195 young protein-coding genes, which originated 3 to 35 million years ago in Drosophila. Knocking down expression with RNA interfe... Cytoplasmic Partitioning of P Granule Components Is Not Required to Specify the Germline in C. elegans [作者：Gallo, CM; Wang, JT; Motegi, F; Seydoux, G,期刊：Science, 页码：1685-1689 , 文章类型： Article，,卷期：2010年330-6011] Asymmetric segregation of P granules during the first four divisions of the Caenorhabditis elegans embryo is a classic example of cytoplasmic partitioning of germline determinants. It is thought that asymmetric partition... Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor [作者：Barnett, BP; Hwang, YS; Taylor, MS; Kirchner, H; Pfluger, PT; Bernard, V; Lin, YY; Bowers, EM; Mukherjee, C; Song, WJ; Longo, PA; Leahy, DJ; Hussain, MA; Tschop, MH; Boeke, JD; Cole, PA,期刊：Science, 页码：1689-1692 , 文章类型： Article，,卷期：2010年330-6011] Ghrelin is a gastric peptide hormone that stimulates weight gain in vertebrates. The biological activities of ghrelin require octanoylation of the peptide on Ser(3), an unusual posttranslational modification that is cata... The Cellular and Physiological Mechanism of Wing-Body Scaling in Manduca sexta [作者：Nijhout, HF; Grunert, LW,期刊：Science, 页码：1693-1695 , 文章类型： Article，,卷期：2010年330-6011] In animals, appendages develop in proportion to overall body size; when individual size varies, appendages covary proportionally. In insects with complete metamorphosis, adult appendages develop from precursor tissues ca... Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans [作者：Mold, JE; Venkatasubrahmanyam, S; Burt, TD; Michaelsson, J; Rivera, JM; Galkina, SA; Weinberg, K; Stoddart, CA; McCune, JM,期刊：Science, 页码：1695-1699 , 文章类型： Article，,卷期：2010年330-6011] Although the mammalian immune system is generally thought to develop in a linear fashion, findings in avian and murine species argue instead for the developmentally ordered appearance (or "layering") of distinct hematopo...