- Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation
[作者:Muenzner, P; Bachmann, V; Zimmermann, W; Hentschel, J; Hauck, CR,期刊:Science, 页码:1197-1201 , 文章类型: Article,,卷期:2010年329-5996]
- Colonization of mucosal surfaces is the key initial step in most bacterial infections. One mechanism protecting the mucosa is the rapid shedding of epithelial cells, also termed exfoliation, but it is unclear how pathoge...
- Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation
[作者:Bungard, D; Fuerth, BJ; Zeng, PY; Faubert, B; Maas, NL; Viollet, B; Carling, D; Thompson, CB; Jones, RG; Berger, SL,期刊:Science, 页码:1201-1205 , 文章类型: Article,,卷期:2010年329-5996]
- The mammalian adenosine monophosphate-activated protein kinase (AMPK) is a serine-threonine kinase protein complex that is a central regulator of cellular energy homeostasis. However, the mechanisms by which AMPK mediate...
- The Junctional Adhesion Molecule JAML Is a Costimulatory Receptor for Epithelial gamma delta T Cell Activation
[作者:Witherden, DA; Verdino, P; Rieder, SE; Garijo, O; Mills, RE; Teyton, L; Fischer, WH; Wilson, IA; Havran, WL,期刊:Science, 页码:1205-1210 , 文章类型: Article,,卷期:2010年329-5996]
- gamma delta T cells present in epithelial tissues provide a crucial first line of defense against environmental insults, including infection, trauma, and malignancy, yet the molecular events surrounding their activation ...
- Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family
[作者:Cui, JX; Yao, Q; Li, S; Ding, XJ; Lu, QH; Mao, HB; Liu, LP; Zheng, N; Chen, S; Shao, F,期刊:Science, 页码:1215-1218 , 文章类型: Article,,卷期:2010年329-5996]
- A family of bacterial effectors including Cif homolog from Burkholderia pseudomallei (CHBP) and Cif from Enteropathogenic Escherichia coli (EPEC) adopt a functionally important papain-like hydrolytic fold. We show here t...
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