- PTP sigma Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration
[作者：Shen, YJ; Tenney, AP; Busch, SA; Horn, KP; Cuascut, FX; Liu, K; He, ZG; Silver, J; Flanagan, JG,期刊：Science, 页码：592-596 , 文章类型： Article，,卷期：2009年326-5952]
- Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been identified. We showed that a transmembrane protein tyrosine phos...
- Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase
[作者：Ma, SM; Li, JWH; Choi, JW; Zhou, H; Lee, KKM; Moorthie, VA; Xie, XK; Kealey, JT; Da Silva, NA; Vederas, JC; Tang, Y,期刊：Science, 页码：589-592 , 文章类型： Article，,卷期：2009年326-5952]
- Highly reducing iterative polyketide synthases are large, multifunctional enzymes that make important metabolites in fungi, such as lovastatin, a cholesterol-lowering drug from Aspergillus terreus. We report efficient ex...
- Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome
[作者：Lombardi, VC; Ruscetti, FW; Das Gupta, J; Pfost, MA; Hagen, KS; Peterson, DL; Ruscetti, SK; Bagni, RK; Petrow-Sadowski, C; Gold, B; Dean, M; Silverman, RH; Mikovits, JA,期刊：Science, 页码：585-589 , 文章类型： Article，,卷期：2009年326-5952]
- Chronic fatigue syndrome (CFS) is a debilitating disease of unknown etiology that is estimated to affect 17 million people worldwide. Studying peripheral blood mononuclear cells (PBMCs) from CFS patients, we identified D...
- Pathogenesis of Chytridiomycosis, a Cause of Catastrophic Amphibian Declines
[作者：Voyles, J; Young, S; Berger, L; Campbell, C; Voyles, WF; Dinudom, A; Cook, D; Webb, R; Alford, RA; Skerratt, LF; Speare, R,期刊：Science, 页码：582-585 , 文章类型： Article，,卷期：2009年326-5952]
- The pathogen Batrachochytrium dendrobatidis (Bd), which causes the skin disease chytridiomycosis, is one of the few highly virulent fungi in vertebrates and has been implicated in worldwide amphibian declines. However, t...
- Metagenome of a Versatile Chemolithoautotroph from Expanding Oceanic Dead Zones
[作者：Walsh, DA; Zaikova, E; Howes, CG; Song, YC; Wright, JJ; Tringe, SG; Tortell, PD; Hallam, SJ,期刊：Science, 页码：578-582 , 文章类型： Article，,卷期：2009年326-5952]
- Oxygen minimum zones, also known as oceanic "dead zones," are widespread oceanographic features currently expanding because of global warming. Although inhospitable to metazoan life, they support a cryptic microbiota who...
- A Cdc20-APC Ubiquitin Signaling Pathway Regulates Presynaptic Differentiation
[作者：Yang, Y; Kim, AH; Yamada, T; Wu, B; Bilimoria, PM; Ikeuchi, Y; de la Iglesia, N; Shen, J; Bonni, A,期刊：Science, 页码：575-578 , 文章类型： Article，,卷期：2009年326-5952]
- Presynaptic axonal differentiation is essential for synapse formation and the establishment of neuronal circuits. However, the mechanisms that coordinate presynaptic development in the brain are largely unknown. We found...
- Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
[作者：Yauch, RL; Dijkgraaf, GJP; Alicke, B; Januario, T; Ahn, CP; Holcomb, T; Pujara, K; Stinson, J; Callahan, CA; Tang, T; Bazan, JF; Kan, Z; Seshagiri, S; Hann, CL; Gould, SE; Low, JA; Rudin, CM; de Sauvage, FJ,期刊：Science, 页码：572-574 , 文章类型： Article，,卷期：2009年326-5952]
- The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a drug that inhibits Hh signaling by targeting the serpentine rec...
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