- In planta gene targeting
[作者:Fauser, F; Roth, N; Pacher, M; Ilg, G; Sanchez-Fernandez, R; Biesgen, C; Puchta, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7535-7540 , 文章类型: Article,,卷期:2012年109-19]
- The development of designed site-specific endonucleases boosted the establishment of gene targeting (GT) techniques in a row of different species. However, the methods described in plants require a highly efficient trans...
- Visual attention and the acquisition of information in human crowds
[作者:Gallup, AC; Hale, JJ; Sumpter, DJT; Garnier, S; Kacelnik, A; Krebs, JR; Couzin, ID,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7245-7250 , 文章类型: Article,,卷期:2012年109-19]
- Pedestrian crowds can form the substrate of important socially contagious behaviors, including propagation of visual attention, violence, opinions, and emotional state. However, relating individual to collective behavior...
- A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system
[作者:Lowe, EC; Basle, A; Czjzek, M; Firbank, SJ; Bolam, DN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7298-7303 , 文章类型: Article,,卷期:2012年109-19]
- Signaling across the membrane in response to extracellular stimuli is essential for survival of all cells. In bacteria, responses to environmental changes are predominantly mediated by two-component systems, which are ty...
- Accumulation of impact markers in desert wetlands and implications for the Younger Dryas impact hypothesis
[作者:Pigati, JS; Latorre, C; Rech, JA; Betancourt, JL; Martinez, KE; Budahn, JR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7208-7212 , 文章类型: Article,,卷期:2012年109-19]
- The Younger Dryas impact hypothesis contends that an extraterrestrial object exploded over North America at 12.9 ka, initiating the Younger Dryas cold event, the extinction of many North American megafauna, and the demis...
- Computational adaptive optics for broadband optical interferometric tomography of biological tissue
[作者:Adie, SG; Graf, BW; Ahmad, A; Carney, PS; Boppart, SA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7175-7180 , 文章类型: Article,,卷期:2012年109-19]
- Aberrations in optical microscopy reduce image resolution and contrast, and can limit imaging depth when focusing into biological samples. Static correction of aberrations may be achieved through appropriate lens design,...
- Computational design of a protein crystal
[作者:Lanci, CJ; MacDermaid, CM; Kang, SG; Acharya, R; North, B; Yang, X; Qiu, XJ; DeGrado, WF; Saven, JG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7304-7309 , 文章类型: Article,,卷期:2012年109-19]
- Protein crystals have catalytic and materials applications and are central to efforts in structural biology and therapeutic development. Designing predetermined crystal structures can be subtle given the complexity of pr...
- Action controls dopaminergic enhancement of reward representations
[作者:Hayakawa, K; Pham, LDD; Katusic, ZS; Arai, K; Lo, EH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7505-7510 , 文章类型: Article,,卷期:2012年109-19]
- Crosstalk between the brain and systemic responses in blood is increasingly suspected of playing critical roles in stroke. However, how this communication takes place remains to be fully understood. Here, we show that re...
- Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice
[作者:Wu, L; Parekh, VV; Gabriel, CL; Bracy, DP; Marks-Shulman, PA; Tamboli, RA; Kim, S; Mendez-Fernandez, YV; Besra, GS; Lomenick, JP; Williams, B; Wasserman, DH; Van Kaer, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1143-E1152 , 文章类型: Article,,卷期:2012年109-19]
- Obesity triggers a low-grade systemic inflammation, which plays an important role in the development of obesity-associated metabolic diseases. In searching for links between lipid accumulation and chronic inflammation, w...
- Conserved and essential transcription factors for cellulase gene expression in ascomycete fungi
[作者:Coradetti, ST; Craig, JP; Xiong, Y; Shock, T; Tian, CG; Glass, NL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7397-7402 , 文章类型: Article,,卷期:2012年109-19]
- Rational engineering of filamentous fungi for improved cellulase production is hampered by our incomplete knowledge of transcriptional regulatory networks. We therefore used the model filamentous fungus Neurospora crassa...
- Eukaryotic-type plastid nucleoid protein pTAC3 is essential for transcription by the bacterial-type plastid RNA polymerase
[作者:Yagi, Y; Ishizaki, Y; Nakahira, Y; Tozawa, Y; Shiina, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7541-7546 , 文章类型: Article,,卷期:2012年109-19]
- Plastid transcription is mediated by two distinct types of RNA polymerases (RNAPs), bacterial-type RNAP (PEP) and phage-type RNAP (NEP). Recent genomic and proteomic studies revealed that higher plants have lost most pro...
- Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis
[作者:Koch, M; Mollenkopf, HJ; Klemm, U; Meyer, TF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1153-E1162 , 文章类型: Article,,卷期:2012年109-19]
- Helicobacter pylori is a gastric pathogen responsible for a high disease burden worldwide. Deregulated inflammatory responses, possibly involving macrophages, are implicated in H. pylori-induced pathology, and microRNAs,...
- Influenza A virus entry into cells lacking sialylated N-glycans
[作者:de Vries, E; de Vries, RP; Wienholts, MJ; Floris, CE; Jacobs, MS; van den Heuvel, A; Rottier, PJM; de Haan, CAM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7457-7462 , 文章类型: Article,,卷期:2012年109-19]
- Influenza A virus (IAV) enters host cells after attachment of its hemagglutinin (HA) to surface-exposed sialic acid. Sialylated N-linked glycans have been reported to be essential for IAV entry [Chu VC, Whittaker GR (200...
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