- Phosphorylation regulates human OCT4
[作者:Brumbaugh, J; Hou, ZG; Russell, JD; Howden, SE; Yu, PZ; Ledvina, AR; Coon, JJ; Thomson, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7162-7168 , 文章类型: Article,,卷期:2012年109-19]
- The transcription factor OCT4 is fundamental to maintaining pluripotency and self-renewal. To better understand protein-level regulation of OCT4, we applied liquid chromatography-MS to identify 14 localized sites of phos...
- Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis
[作者:Elsholz, AKW; Turgay, K; Michalik, S; Hessling, B; Gronau, K; Oertel, D; Mader, U; Bernhardt, J; Becher, D; Hecker, M; Gerth, U,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7451-7456 , 文章类型: Article,,卷期:2012年109-19]
- Reversible protein phosphorylation is an important and ubiquitous protein modification in all living cells. Here we report that protein phosphorylation on arginine residues plays a physiologically significant role. We de...
- Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG
[作者:Qi, YCB; Garren, EJ; Shu, XK; Tsien, RY; Jin, YS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7499-7504 , 文章类型: Article,,卷期:2012年109-19]
- We describe a method for light-inducible and tissue-selective cell ablation using a genetically encoded photosensitizer, miniSOG (mini singlet oxygen generator). miniSOG is a newly engineered fluorescent protein of 106 a...
- Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns
[作者:Miyako, E; Deguchi, T; Nakajima, Y; Yudasaka, M; Hagihara, Y; Horie, M; Shichiri, M; Higuchi, Y; Yamashita, F; Hashida, M; Shigeri, Y; Yoshida, Y; Iijima, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7523-7528 , 文章类型: Article,,卷期:2012年109-19]
- The development of optical methods to control cellular functions is important for various biological applications. In particular, heat shock promoter-mediated gene expression systems by laser light are attractive targets...
- Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade
[作者:Yang, DL; Yao, J; Mei, CS; Tong, XH; Zeng, LJ; Li, Q; Xiao, LT; Sun, TP; Li, JG; Deng, XW; Lee, CM; Thomashow, MF; Yang, YN; He, ZH; He, SY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1192-E1200 , 文章类型: Article,,卷期:2012年109-19]
- Plants must effectively defend against biotic and abiotic stresses to survive in nature. However, this defense is costly and is often accompanied by significant growth inhibition. How plants coordinate the fluctuating gr...
- Growth-induced hormone dilution can explain the dynamics of plant root cell elongation
[作者:Band, LR; Ubeda-Tomas, S; Dyson, RJ; Middleton, AM; Hodgman, TC; Owen, MR; Jensen, OE; Bennett, MJ; King, JR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7577-7582 , 文章类型: Article,,卷期:2012年109-19]
- In the elongation zone of the Arabidopsis thaliana plant root, cells undergo rapid elongation, increasing their length by similar to 10-fold over 5 h while maintaining a constant radius. Although progress is being made i...
- Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use
[作者:Kleiner, M; Wentrup, C; Lott, C; Teeling, H; Wetzel, S; Young, J; Chang, YJ; Shah, M; VerBerkmoes, NC; Zarzycki, J; Fuchs, G; Markert, S; Hempel, K; Voigt, B; Becher, D; Liebekeh, M; Lalk, M; Albrecht, D; Hecker, M; Schweder, T; Dubilier, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1173-E1182 , 文章类型: Article,,卷期:2012年109-19]
- Low nutrient and energy availability has led to the evolution of numerous strategies for overcoming these limitations, of which symbiotic associations represent a key mechanism. Particularly striking are the associations...
- MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor
[作者:Williams, KC; Renthal, NE; Condon, JC; Gerard, RD; Mendelson, CR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7529-7534 , 文章类型: Article,,卷期:2012年109-19]
- During pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) activity, but labor is facilitated by a series of events that impair PR function. Previously, we discovered that miR-200 family m...
- Midlife gene expressions identify modulators of aging through dietary interventions
[作者:Zhou, B; Yang, L; Li, SF; Huang, JL; Chen, HY; Hou, L; Wang, JB; Green, CD; Yan, Z; Huang, X; Kaeberlein, M; Zhu, L; Xiao, HS; Liu, Y; Han, JDJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1201-E1209 , 文章类型: Article,,卷期:2012年109-19]
- Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related ph...
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