- MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme
[作者:Suh, SS; Yoo, JY; Nuovo, GJ; Jeon, YJ; Kim, S; Lee, TJ; Kim, T; Bakacs, A; Alder, H; Kaur, B; Aqeilan, RI; Pichiorri, F; Croce, CM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5316-5321 , 文章类型: Article,,卷期:2012年109-14]
- MicroRNAs (miRNAs) are increasingly implicated in regulating cancer initiation and progression. In this study, twomiRNAs, miR-25 and -32, are identified as p53-repressed miRNAs by p53-dependent negative regulation of the...
- Spatial and temporal arrival patterns of Madagascar's vertebrate fauna explained by distance, ocean currents, and ancestor type
[作者:Samonds, KE; Godfrey, LR; Ali, JR; Goodmand, SM; Vences, M; Sutherland, MR; Irwin, MT; Krause, DW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5352-5357 , 文章类型: Article,,卷期:2012年109-14]
- How, when, and from where Madagascar's vertebrates arrived on the island is poorly known, and a comprehensive explanation for the distribution of its organisms has yet to emerge. We begin to break that impasse by analyzi...
- TWIK1, a unique background channel with variable ion selectivity
[作者:Chatelain, FC; Bichet, D; Douguet, D; Feliciangeli, S; Bendahhou, S; Reichold, M; Warth, R; Barhanin, J; Lesage, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5499-5504 , 文章类型: Article,,卷期:2012年109-14]
- TWIK1 belongs to the family of background K+ channels with two pore domains. In native and transfected cells, TWIK1 is detected mainly in recycling endosomes. In principal cells in the kidney, TWIK1 gene inactivation lea...
- High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death
[作者:Fox, JT; Sakamuru, S; Huang, RL; Teneva, N; Simmons, SO; Xia, MH; Tice, RR; Austin, CP; Myung, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5423-5428 , 文章类型: Article,,卷期:2012年109-14]
- Human ATAD5 is a biomarker for identifying genotoxic compounds because ATAD5 protein levels increase posttranscriptionally in response to DNA damage. We screened over 4,000 compounds with a cell-based quantitative high-t...
- Maternal siRNAs as regulators of parental genome imbalance and gene expression in endosperm of Arabidopsis seeds
[作者:Lu, J; Zhang, CQ; Baulcombe, DC; Chen, ZJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5529-5534 , 文章类型: Article,,卷期:2012年109-14]
- Seed size is important to crop domestication and natural selection and is affected by the balance of maternal and paternal genomes in endosperm. Endosperm, like placenta in mammals, provides reserves to the developing em...
- Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
[作者:Sebastian, D; Hernandez-Alvarez, MI; Segales, J; Sorianello, E; Munoz, JP; Sala, D; Waget, A; Liesa, M; Paz, JC; Gopalacharyulu, P; Oresic, M; Pich, S; Burcelin, R; Palacin, M; Zorzano, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5523-5528 , 文章类型: Article,,卷期:2012年109-14]
- Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal mitochondrial function is ensured by a quality-control system tightly coupled to fusion and fission. In this connection, mitofusin 2 ...
- Prokineticin 2 is an endangering mediator of cerebral ischemic injury
[作者:Cheng, MY; Lee, AG; Culbertson, C; Sun, GH; Talati, RK; Manley, NC; Li, XH; Zhao, H; Lyons, DM; Zhou, QY; Steinberg, GK; Sapolsky, RM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5475-5480 , 文章类型: Article,,卷期:2012年109-14]
- Stroke causes brain dysfunction and neuron death, and the lack of effective therapies heightens the need for new therapeutic targets. Here we identify prokineticin 2 (PK2) as a mediator for cerebral ischemic injury. PK2 ...
- Two independent switches regulate cytoplasmic dynein's processivity and directionality
[作者:Walter, WJ; Koonce, MP; Brenner, B; Steffen, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5289-5293 , 文章类型: Article,,卷期:2012年109-14]
- Cytoplasmic dynein is a microtubule-based molecular motor that participates in a multitude of cell activities, from cell division to organelle transport. Unlike kinesin and myosin, where different tasks are performed by ...
- Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells
[作者:Kubicek, S; Gilbert, JC; Fomina-Yadlin, D; Gitlin, AD; Yuan, Y; Wagner, FF; Holson, EB; Luo, TP; Lewis, TA; Taylor, B; Gupta, S; Shamji, AF; Wagner, BK; Clemons, PA; Schreiber, SL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5364-5369 , 文章类型: Article,,卷期:2012年109-14]
- Under the instruction of cell-fate-determining, DNA-binding transcription factors, chromatin-modifying enzymes mediate and maintain cell states throughout development in multicellular organisms. Currently, small molecule...
- Effect of channel mutations on the uptake and release of the retinal ligand in opsin
[作者:Piechnick, R; Ritter, E; Hildebrand, PW; Ernst, OP; Scheerer, P; Hofmann, KP; Heck, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5247-5252 , 文章类型: Article,,卷期:2012年109-14]
- In the retinal binding pocket of rhodopsin, a Schiff base links the retinal ligand covalently to the Lys296 side chain. Light transforms the inverse agonist 11-cis-retinal into the agonist all-trans-retinal, leading to t...
- Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
[作者:Zhao, J; Jitkaew, S; Cai, ZY; Choksi, S; Li, QN; Luo, J; Liu, ZG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5322-5327 , 文章类型: Article,,卷期:2012年109-14]
- Tumor necrosis factor (TNF) is an important inflammatory cytokine and induces many cellular responses, including inflammation, cell proliferation, apoptosis, and necrosis. It is known that receptor interacting protein (R...
- Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197
[作者:Malito, E; Bursulaya, B; Chen, CN; Lo Surdo, P; Picchianti, M; Balducci, E; Biancucci, M; Brock, A; Berti, F; Bottomley, MJ; Nissum, M; Costantino, P; Rappuoli, R; Spraggon, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5229-5234 , 文章类型: Article,,卷期:2012年109-14]
- CRM197 is an enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid substitution (G52E). Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against...
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