- Molecular genetic basis of pod corn (Tunicate maize)
[作者:Wingen, LU; Munster, T; Faigl, W; Deleu, W; Sommer, H; Saedler, H; Theissen, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7115-7120 , 文章类型: Article,,卷期:2012年109-18]
- Pod corn is a classic morphological mutant of maize in which the mature kernels of the cob are covered by glumes, in contrast to generally grown maize varieties in which kernels are naked. Pod corn, known since pre-Colum...
- Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
[作者:Ye, JB; Mancuso, A; Tong, XM; Ward, PS; Fan, J; Rabinowitz, JD; Thompson, CB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6904-6909 , 文章类型: Article,,卷期:2012年109-18]
- Despite the fact that most cancer cells display high glycolytic activity, cancer cells selectively express the less active M2 isoform of pyruvate kinase (PKM2). Here we demonstrate that PKM2 expression makes a critical r...
- A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence
[作者:Beh, LY; Colwell, LJ; Francis, NJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1063-E1071 , 文章类型: Article,,卷期:2012年109-18]
- Polycomb Group (PcG) proteins mediate heritable gene silencing by modifying chromatin structure. An essential PcG complex, PRC1, compacts chromatin and inhibits chromatin remodeling. In Drosophila melanogaster, the intri...
- Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy
[作者:Wei, H; Xiang, LM; Wayne, AS; Chertov, O; FitzGerald, DJ; Bera, TK; Pastan, I,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6898-6903 , 文章类型: Article,,卷期:2012年109-18]
- HA22 is a recombinant immunotoxin composed of an anti-CD22 Fv fused to a portion of Pseudomonas exotoxin A. HA22 produced a high rate of complete remissions in drug-resistant hairy cell leukemia and has a lower response ...
- Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity
[作者:Larson, JD; Thurman, JM; Rubtsov, AV; Claypool, D; Marrack, P; van Dyk, LF; Torres, RM; Pelanda, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E1092-E1100 , 文章类型: Article,,卷期:2012年109-18]
- Gammaherpesvirus infections, such as those caused by EBV, have been suggested to promote the development of autoimmunity. To test this idea, we infected healthy WT and lupus-prone B6. Sle123 mice with an EBV-related and ...
- Regulation of selective autophagy onset by a Ypt/Rab GTPase module
[作者:Lipatova, Z; Belogortseva, N; Zhang, XQ; Kim, J; Taussig, D; Segev, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6981-6986 , 文章类型: Article,,卷期:2012年109-18]
- The key regulators of intracellular trafficking, Ypt/Rab GTPases, are stimulated by specific upstream activators and, when activated, recruit specific downstream effectors to mediate membrane-transport events. The yeast ...
- Inoculation of bats with European Geomyces destructans supports the novel pathogen hypothesis for the origin of white-nose syndrome
[作者:Warnecke, L; Turner, JM; Bollinger, TK; Lorch, JM; Misra, V; Cryan, PM; Wibbelt, G; Blehert, DS; Willis, CKR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6999-7003 , 文章类型: Article,,卷期:2012年109-18]
- White-nose syndrome (WNS) is an emerging disease of hibernating bats associated with cutaneous infection by the fungus Geomyces destructans (Gd), and responsible for devastating declines of bat populations in eastern Nor...
- Near attack conformers dominate beta-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate
[作者:Griffin, JL; Bowler, MW; Baxter, NJ; Leigh, KN; Dannatt, HRW; Hounslow, AM; Blackburn, GM; Webster, CE; Cliff, MJ; Waltho, JP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6910-6915 , 文章类型: Article,,卷期:2012年109-18]
- Experimental observations of fluoromagnesate and fluoroaluminate complexes of beta-phosphoglucomutase (beta-PGM) have demonstrated the importance of charge balance in transition-state stabilization for phosphoryl transfe...
- Nest-building orangutans demonstrate engineering know-how to produce safe, comfortable beds
[作者:van Casteren, A; Sellers, WI; Thorpe, SKS; Coward, S; Crompton, RH; Myatt, JP; Ennos, AR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6873-6877 , 文章类型: Article,,卷期:2012年109-18]
- Nest-building orangutans must daily build safe and comfortable nest structures in the forest canopy and do this quickly and effectively using the branches that surround them. This study aimed to investigate the mechanica...
- Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension
[作者:Dahlgaard, K; Jung, A; Qvortrup, K; Clausen, H; Kjaerulff, O; Wandall, HH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6987-6992 , 文章类型: Article,,卷期:2012年109-18]
- Glycosphingolipids (GSLs) are of fundamental importance in the nervous system. However, the molecular details associated with GSL function are largely unknown, in part because of the complexity of GSL biosynthesis in ver...
- Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels
[作者:Osteen, JD; Barro-Soria, R; Robey, S; Sampson, KJ; Kass, RS; Larsson, HP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:7103-7108 , 文章类型: Article,,卷期:2012年109-18]
- KCNQ1 (Kv7.1) is a unique member of the superfamily of voltage-gated K+ channels in that it displays a remarkable range of gating behaviors tuned by coassembly with different beta subunits of the KCNE family of proteins....
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