- Regulation of inflorescence architecture by intertissue layer ligand-receptor communication between endodermis and phloem
[作者:Uchida, N; Lee, JS; Horst, RJ; Lai, HH; Kajita, R; Kakimoto, T; Tasaka, M; Torii, KU,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6337-6342 , 文章类型: Article,,卷期:2012年109-16]
- Multicellular organisms achieve final body shape and size by coordinating cell proliferation, expansion, and differentiation. Loss of function in the Arabidopsis ERECTA (ER) receptor-kinase gene confers characteristic co...
- Structure of p73 DNA-binding domain tetramer modulates p73 transactivation
[作者:Ethayathulla, AS; Tse, PW; Monti, P; Nguyen, S; Inga, A; Fronza, G; Viadiu, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6066-6071 , 文章类型: Article,,卷期:2012年109-16]
- The transcription factor p73 triggers developmental pathways and overlaps stress-induced p53 transcriptional pathways. How p53-family response elements determine and regulate transcriptional specificity remains an unsolv...
- Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages
[作者:Schroder, K; Irvine, KM; Taylor, MS; Bokil, NJ; Cao, KAL; Masterman, KA; Labzin, LI; Semple, CA; Kapetanovic, R; Fairbairn, L; Akalin, A; Faulkner, GJ; Baillie, JK; Gongora, M; Daub, CO; Kawaji, H; McLachlan, GJ; Goldman, N; Grimmond, SM; Carninci, P; Suzuki, H; Hayashizaki, Y; Lenhard, B; Hume, DA; Sweet, MJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E944-E953 , 文章类型: Article,,卷期:2012年109-16]
- Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing interspecies differences in the tr...
- Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation
[作者:Malik, M; Jividen, K; Padmakumar, VC; Cataisson, C; Li, LW; Lee, J; Howard, OMZ; Yuspa, SH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6130-6135 , 文章类型: Article,,卷期:2012年109-16]
- Nuclear translocation of cytosolic CLIC4 is an essential feature of its proapoptotic and prodifferentiation functions. Here we demonstrate that CLIC4 is induced concurrently with inducible nitric oxide synthase (iNOS) an...
- Induction of lignocellulose-degrading enzymes in Neurospora crassa by cellodextrins
[作者:Znameroski, EA; Coradetti, ST; Roche, CM; Tsai, JC; Iavarone, AT; Cate, JHD; Glass, NL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6012-6017 , 文章类型: Article,,卷期:2012年109-16]
- Neurospora crassa colonizes burnt grasslands in the wild and metabolizes both cellulose and hemicellulose from plant cell walls. When switched from a favored carbon source such as sucrose to cellulose, N. crassa dramatic...
- Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals
[作者:Gonzalez-Gutierrez, G; Lukk, T; Agarwal, V; Papke, D; Nair, SK; Grosman, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6331-6336 , 文章类型: Article,,卷期:2012年109-16]
- The determination of structural models of the various stable states of an ion channel is a key step toward the characterization of its conformational dynamics. In the case of nicotinic-type receptors, different structure...
- Natural variation in a polyamine transporter determines paraquat tolerance in Arabidopsis
[作者:Fujita, M; Fujita, Y; Iuchi, S; Yamada, K; Kobayashi, Y; Urano, K; Kobayashi, M; Yamaguchi-Shinozaki, K; Shinozaki, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6343-6347 , 文章类型: Article,,卷期:2012年109-16]
- Polyamines (PAs) are ubiquitous, polycationic compounds that are essential for the growth and survival of all organisms. Although the PA-uptake system plays a key role in mammalian cancer and in plant survival, the under...
- Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death
[作者:Noh, KM; Hwang, JY; Follenzi, A; Athanasiadou, R; Miyawaki, T; Greally, JM; Bennett, MVL; Zukin, RS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E962-E971 , 文章类型: Article,,卷期:2012年109-16]
- Dysregulation of the transcriptional repressor element-1 silencing transcription factor (REST)/neuron-restrictive silencer factor is important in a broad range of diseases, including cancer, diabetes, and heart disease. ...
- RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities
[作者:Barczak, AK; Gomez, JE; Kaufmann, BB; Hinson, ER; Cosimi, L; Borowsky, ML; Onderdonk, AB; Stanley, SA; Kaur, D; Bryant, KF; Knipe, DM; Sloutsky, A; Hung, DT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6217-6222 , 文章类型: Article,,卷期:2012年109-16]
- With rising rates of drug-resistant infections, there is a need for diagnostic methods that rapidly can detect the presence of pathogens and reveal their susceptibility to antibiotics. Here we propose an approach to diag...
- Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment
[作者:Wang, F; Marshall, CB; Yamamoto, K; Li, GY; Gasmi-Seabrook, GMC; Okada, H; Mak, TW; Ikura, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:6078-6083 , 文章类型: Article,,卷期:2012年109-16]
- Forkhead box class O 3a (FOXO3a) is a transcription factor and tumor suppressor linked to longevity that determines cell fate through activating transcription of cell differentiation, survival, and apoptotic genes. Recru...
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