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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共96条记录   The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue [作者：Harman, MW; Dunham-Ems, SM; Caimano, MJ; Belperron, AA; Bockenstedt, LK; Fu, HC; Radolf, JD; Wolgemuth, CW,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：3059-3064 , 文章类型： Article，,卷期：2012年109-8] The Lyme disease spirochete Borrelia burgdorferi exists in nature in an enzootic cycle that involves the arthropod vector Ixodes scapularis and mammalian reservoirs. To disseminate within and between these hosts, spiroch... Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011 [作者：Grad, YH; Lipsitch, M; Feldgarden, M; Arachchi, HM; Cerqueira, GC; FitzGerald, M; Godfrey, P; Haas, BJ; Murphy, CI; Russ, C; Sykes, S; Walker, BJ; Wortman, JR; Young, S; Zeng, QD; Abouelleil, A; Bochicchio, J; Chauvin, S; DeSmet, T; Gujja, S; McCowan, C; Montmayeur, A; Steelman, S; Frimodt-Moller, J; Petersen, AM; Struve, C; Krogfelt, KA; Bingen, E; Weill, FX; Lander, ES; Nusbaum, C; Birren, BW; Hung, DT; Hanage, WP,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：3065-3070 , 文章类型： Article，,卷期：2012年109-8] The degree to which molecular epidemiology reveals information about the sources and transmission patterns of an outbreak depends on the resolution of the technology used and the samples studied. Isolates of Escherichia ... Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection [作者：Terry, LJ; Vastag, L; Rabinowitz, JD; Shenk, T,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：3071-3076 , 文章类型： Article，,卷期：2012年109-8] Human cytomegalovirus (HCMV) modulates numerous cellular signaling pathways. Alterations in signaling are evident from the broad changes in cellular phosphorylation that occur during HCMV infection and from the altered a... RNA virus microRNA that mimics a B-cell oncomiR [作者：Kincaid, RP; Burke, JM; Sullivan, CS,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：3077-3082 , 文章类型： Article，,卷期：2012年109-8] MicroRNAs (miRNAs) are small RNAs that play a regulatory role in numerous and diverse eukaryotic cellular processes. Virus-encoded miRNAs have garnered much interest, although the functions of most remain to be deciphere... Subtype and pathway specific responses to anticancer compounds in breast cancer [作者：Heiser, LM; Sadanandam, A; Kuo, WL; Benz, SC; Goldstein, TC; Ng, S; Gibb, WJ; Wang, NJ; Ziyad, S; Tong, F; Bayani, N; Hu, Z; Billig, JI; Dueregger, A; Lewis, S; Jakkula, L; Korkola, JE; Durinck, S; Pepin, F; Guan, YH; Purdom, E; Neuvial, P; Bengtsson, H; Wood, KW; Smith, PG; Vassilev, LT; Hennessy, BT; Greshock, J; Bachman, KE; Hardwicke, MA; Park, JW; Marton, LJ; Wolf, DM; Collisson, EA; Neve, RM; Mills, GB; Speed, TP; Feiler, HS; Wooster, RF; Haussler, D; Stuart, JM; Gray, JW; Spellman, PT,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：2724-2729 , 文章类型： Article，,卷期：2012年109-8] Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtype... Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen [作者：Mendes-Pereira, AM; Sims, D; Dexter, T; Fenwick, K; Assiotis, I; Kozarewa, I; Mitsopoulos, C; Hakas, J; Zvelebil, M; Lord, CJ; Ashworth, A,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：2730-2735 , 文章类型： Article，,卷期：2012年109-8] Therapies that target estrogen signaling have made a very considerable contribution to reducing mortality from breast cancer. However, resistance to tamoxifen remains a major clinical problem. Here we have used a genome-... The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway [作者：Jin, K; Kong, XJ; Shah, T; Penet, MF; Wildes, F; Sgroi, DC; Ma, XJ; Huang, Y; Kallioniemi, A; Landberg, G; Bieche, I; Wu, XY; Lobie, PE; Davidson, NE; Bhujwalla, ZM; Zhu, T; Sukumar, S,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：2736-2741 , 文章类型： Article，,卷期：2012年109-8] Multiple factors including long-term treatment with tamoxifen are involved in the development of selective estrogen receptor (ER) modulator resistance in ER alpha-positive breast cancer. Many underlying molecular events ... Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch [作者：Haughian, JM; Pinto, MP; Harrell, JC; Bliesner, BS; Joensuu, KM; Dye, WW; Sartorius, CA; Tan, AC; Heikkila, P; Perou, CM; Horwitz, KB,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：2742-2747 , 文章类型： Article，,卷期：2012年109-8] Luminal breast cancers express estrogen (ER) and/or progesterone (PR) receptors and respond to hormone therapies. Basal-like "triple negative" cancers lack steroid receptors but are cytokeratin (CK) 5-positive and requir... Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation [作者：Price, PA; Jin, JP; Goldman, WE,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：3083-3088 , 文章类型： Article，,卷期：2012年109-8] Disease progression of primary pneumonic plague is biphasic, consisting of a preinflammatory and a proinflammatory phase. During the long preinflammatory phase, bacteria replicate to high levels, seemingly uninhibited by... Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention [作者：Magro, M; Mas, V; Chappell, K; Vazquez, M; Cano, O; Luque, D; Terron, MC; Melero, JA; Palomo, C,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：3089-3094 , 文章类型： Article，,卷期：2012年109-8] Human respiratory syncytial virus (hRSV) is the most important viral agent of pediatric respiratory infections worldwide. The only specific treatment available today is a humanized monoclonal antibody (Palivizumab) direc... A neurophysiological-metabolic model for burst suppression [作者：Ching, SN; Purdon, PL; Vijayan, S; Kopell, NJ; Brown, EN,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：3095-3100 , 文章类型： Article，,卷期：2012年109-8] Burst suppression is an electroencepholagram (EEG) pattern in which high-voltage activity alternates with isoelectric quiescence. It is characteristic of an inactivated brain and is commonly observed at deep levels of ge... Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal [作者：Grieder, TE; George, O; Tan, HB; George, SR; Le Foll, B; Laviolette, SR; van der Kooy, D,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：3101-3106 , 文章类型： Article，,卷期：2012年109-8] Nicotine, the main psychoactive ingredient of tobacco smoke, induces negative motivational symptoms during withdrawal that contribute to relapse in dependent individuals. The neurobiological mechanisms underlying how the... Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells [作者：Holmes, KA; Hurtado, A; Brown, GD; Launchbury, R; Ross-Innes, CS; Hadfield, J; Odom, DT; Carroll, JS,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：2748-2753 , 文章类型： Article，,卷期：2012年109-8] Estrogen receptor (ER) binds to distal enhancers within the genome and requires additional factors, such as the Forkhead protein FoxA1, for mediating chromatin interactions. We now show that the human Groucho protein, Tr... Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins [作者：Liberal, V; Martinsson-Ahlzen, HS; Liberal, J; Spruck, CH; Widschwendter, M; McGowan, CH; Reed, SI,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：2754-2759 , 文章类型： Article，,卷期：2012年109-8] Cyclin-dependent kinase subunit (Cks) proteins are small cyclin-dependent kinase-interacting proteins that are frequently overexpressed in breast cancer, as well as in a broad spectrum of other human malignancies. Howeve... Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses [作者：Chiba, N; Comaills, V; Shiotani, B; Takahashi, F; Shimada, T; Tajima, K; Winokur, D; Hayashida, T; Willers, H; Brachtel, E; Vivanco, MD; Haber, DA; Zou, L; Maheswaran, S,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：2760-2765 , 文章类型： Article，,卷期：2012年109-8] Homeobox 9 (HOXB9), a nontransforming transcription factor overexpressed in breast cancer, alters tumor cell fate and promotes tumor progression and metastasis. Here we show that HOXB9 confers resistance to ionizing radi... Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737 [作者：Oakes, SR; Vaillant, F; Lim, E; Lee, L; Breslin, K; Feleppa, F; Deb, S; Ritchie, ME; Takano, E; Ward, T; Fox, SB; Generali, D; Smyth, GK; Strasser, A; Huang, DCS; Visvader, JE; Lindeman, GJ,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：2766-2771 , 文章类型： Article，,卷期：2012年109-8] Overexpression of the prosurvival protein BCL-2 is common in breast cancer. Here we have explored its role as a potential therapeutic target in this disease. BCL-2, its anti-apoptotic relatives MCL-1 and BCL-XL, and the ...