- Archaeal ribosomal stalk protein interacts with translation factors in a nucleotide-independent manner via its conserved C terminus
[作者:Nomura, N; Honda, T; Baba, K; Naganuma, T; Tanzawa, T; Arisaka, F; Noda, M; Uchiyama, S; Tanaka, I; Yao, M; Uchiumi, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3748-3753 , 文章类型: Article,,卷期:2012年109-10]
- Protein synthesis on the ribosome requires translational GTPase factors to bind to the ribosome in the GTP-bound form, take individual actions that are coupled with GTP hydrolysis, and dissociate, usually in the GDP-boun...
- Chromosome segregation in Archaea mediated by a hybrid DNA partition machine
[作者:Kalliomaa-Sanford, AK; Rodriguez-Castaneda, FA; McLeod, BN; Latorre-Rosello, V; Smith, JH; Reimann, J; Albers, SV; Barilla, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3754-3759 , 文章类型: Article,,卷期:2012年109-10]
- Eukarya and, more recently, some bacteria have been shown to rely on a cytoskeleton-based apparatus to drive chromosome segregation. In contrast, the factors and mechanisms underpinning this fundamental process are under...
- Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation
[作者:Quana, A; Xue, J; Wielens, J; Smillie, KJ; Anggono, V; Parker, MW; Cousin, MA; Graham, ME; Robinson, PJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3760-3765 , 文章类型: Article,,卷期:2012年109-10]
- Syndapin I (PACSIN 1) is a synaptically enriched membrane tubulating protein that plays important roles in activity-dependent bulk endocytosis and neuronal morphogenesis. While syndapin I is an in vitro phosphoprotein, i...
- Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins
[作者:Briegel, A; Li, XX; Bilwes, AM; Hughes, KT; Jensen, GJ; Crane, BR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3766-3771 , 文章类型: Article,,卷期:2012年109-10]
- Chemoreceptor arrays are supramolecular transmembrane machines of unknown structure that allowbacteria to sense their surroundings and respond by chemotaxis. We have combined X-ray crystallography of purified proteins wi...
- SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency
[作者:Lai, YS; Chang, CW; Pawlik, KM; Zhou, DW; Renfrow, MB; Townes, TM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3772-3777 , 文章类型: Article,,卷期:2012年109-10]
- To gain insight into mechanisms controlling SRY (sex determining region Y)-box 2 (Sox2) protein activity in mouse embryonic stem cells (ESCs), the endogenous Sox2 gene was tagged with FLAG/Hemagglutinin (HA) sequences by...
- The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure
[作者:Adams, CJ; Pike, ACW; Maniam, S; Sharpe, TD; Coutts, AS; Knapp, S; La Thangue, NB; Bullock, AN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3778-3783 , 文章类型: Article,,卷期:2012年109-10]
- Activation of p53 target genes for tumor suppression depends on the stress-specific regulation of transcriptional coactivator complexes. Strap (stress-responsive activator of p300) is activated upon DNA damage by ataxia ...
- Iterative approach to computational enzyme design
[作者:Privett, HK; Kiss, G; Lee, TM; Blomberg, R; Chica, RA; Thomas, LM; Hilvert, D; Houk, KN; Mayo, SL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3790-3795 , 文章类型: Article,,卷期:2012年109-10]
- A general approach for the computational design of enzymes to catalyze arbitrary reactions is a goal at the forefront of the field of protein design. Recently, computationally designed enzymes have been produced for thre...
- The molten globule state is unusually deformable under mechanical force
[作者:Elms, PJ; Chodera, JD; Bustamante, C; Marqusee, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3796-3801 , 文章类型: Article,,卷期:2012年109-10]
- Recently, the role of force in cellular processes has become more evident, and now with advances in force spectroscopy, the response of proteins to force can be directly studied. Such studies have found that native prote...
- Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing
[作者:Matos, MF; Xu, YB; Dulubova, I; Otwinowski, Z; Richardson, JM; Tomchick, DR; Rizo, J; Ho, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3802-3807 , 文章类型: Article,,卷期:2012年109-10]
- Mint adaptor proteins bind to the amyloid precursor protein (APP) and regulate APP processing associated with Alzheimer's disease; however, the molecular mechanisms underlying Mint regulation in APP binding and processin...
- Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability
[作者:Koreny, L; Sobotka, R; Kovarova, J; Gnipova, A; Flegontov, P; Horvath, A; Obornik, M; Ayala, FJ; Lukes, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3808-3813 , 文章类型: Article,,卷期:2012年109-10]
- Heme is an iron-coordinated porphyrin that is universally essential as a protein cofactor for fundamental cellular processes, such as electron transport in the respiratory chain, oxidative stress response, or redox react...
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