- Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice
[作者:Ishimoto, T; Lanaspa, MA; Le, MT; Garcia, GE; Diggle, CP; MacLean, PS; Jackman, MR; Asipu, A; Roncal-Jimenez, CA; Kosugi, T; Rivard, CJ; Maruyama, S; Rodriguez-Iturbe, B; Sanchez-Lozada, LG; Bonthron, DT; Sautin, YY; Johnson, RJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4320-4325 , 文章类型: Article,,卷期:2012年109-11]
- Fructose intake from added sugars correlates with the epidemic rise in obesity, metabolic syndrome, and nonalcoholic fatty liver disease. Fructose intake also causes features of metabolic syndrome in laboratory animals a...
- Induced mutations in circadian clock regulator Mat-a facilitated short-season adaptation and range extension in cultivated barley
[作者:Zakhrabekova, S; Gough, SP; Braumann, I; Muller, AH; Lundqvist, J; Ahmann, K; Dockter, C; Matyszczak, I; Kurowska, M; Druka, A; Waugh, R; Graner, A; Stein, N; Steuernagel, B; Lundqvist, U; Hansson, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4326-4331 , 文章类型: Article,,卷期:2012年109-11]
- Time to flowering has an important impact on yield and has been a key trait in the domestication of crop plants and the spread of agriculture. In 1961, the cultivar Mari (mat-a. 8) was the very first induced early barley...
- Space environment of an asteroid preserved on micrograins returned by the Hayabusa spacecraft
[作者:Nakamura, E; Makishima, A; Moriguti, T; Kobayashi, K; Tanaka, R; Kunihiro, T; Tsujimori, T; Sakaguchi, C; Kitagawa, H; Ota, T; Yachi, Y; Yada, T; Abe, M; Fujimura, A; Ueno, M; Mukai, T; Yoshikawa, M; Kawaguchi, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E624-E629 , 文章类型: Article,,卷期:2012年109-11]
- Records of micrometeorite collisions at down to submicron scales were discovered on dust grains recovered from near-Earth asteroid 25143 (Itokawa). Because the grains were sampled from very near the surface of the astero...
- Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis
[作者:Park, MC; Kang, T; Jin, D; Han, JM; Kim, SB; Park, YJ; Cho, K; Park, YW; Guo, M; He, W; Yang, XL; Schimmel, P; Kim, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E640-E647 , 文章类型: Article,,卷期:2012年109-11]
- Although adaptive systems of immunity against tumor initiation and destruction are well investigated, less understood is the role, if any, of endogenous factors that have conventional functions. Here we show that glycyl-...
- Polar localization of a symbiosis-specific phosphate transporter is mediated by a transient reorientation of secretion
[作者:Pumplin, N; Zhang, XC; Noar, RD; Harrison, MJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E665-E672 , 文章类型: Article,,卷期:2012年109-11]
- The arbuscular mycorrhizal (AM) symbiosis, formed by land plants and AM fungi, evolved an estimated 400 million years ago and has been maintained in angiosperms, gymnosperms, pteridophytes, and some bryophytes as a strat...
- Alternative reading frame selection mediated by a tRNA-like domain of an internal ribosome entry site
[作者:Ren, Q; Wang, QS; Firth, AE; Chan, MMY; Gouw, JW; Guarna, MM; Foster, LJ; Atkins, JF; Jan, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E630-E639 , 文章类型: Article,,卷期:2012年109-11]
- The dicistrovirus intergenic region internal ribosome entry site (IRES) utilizes a unique mechanism, involving P-site tRNA mimicry, to directly assemble 80S ribosomes and initiate translation at a specific non-AUG codon ...
- Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis
[作者:Ho, HYH; Susman, MW; Bikoff, JB; Ryu, YK; Jonas, AM; Hu, L; Kuruvilla, R; Greenberg, ME,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4044-4051 , 文章类型: Article,,卷期:2012年109-11]
- Wnts make up a large family of extracellular signaling molecules that play crucial roles in development and disease. A subset of noncanonical Wnts signal independently of the transcription factor beta-catenin by a mechan...
- Phase separation and rotor self-assembly in active particle suspensions
[作者:Schwarz-Linek, J; Valeriani, C; Cacciuto, A; Cates, ME; Marenduzzo, D; Morozov, AN; Poon, WCK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4052-4057 , 文章类型: Article,,卷期:2012年109-11]
- Adding a nonadsorbing polymer to passive colloids induces an attraction between the particles via the "depletion" mechanism. High enough polymer concentrations lead to phase separation. We combine experiments, theory, an...
- Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity
[作者:No, JH; Dossin, FD; Zhang, YH; Liu, YL; Zhu, W; Feng, XX; Yoo, JA; Lee, E; Wang, K; Hui, R; Freitas-Junior, LH; Oldfield, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4058-4063 , 文章类型: Article,,卷期:2012年109-11]
- We report the results of an in vitro screening assay targeting the intraerythrocytic form of the malaria parasite Plasmodium falciparum using a library of 560 prenyl-synthase inhibitors. Based on "growth-rescue" and enzy...
- Surficial redistribution of fallout (131)iodine in a small temperate catchment
[作者:Landis, JD; Hamm, NT; Renshaw, CE; Dade, WB; Magilligan, FJ; Gartner, JD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4064-4069 , 文章类型: Article,,卷期:2012年109-11]
- Isotopes of iodine play significant environmental roles, including a limiting micronutrient (I-127), an acute radiotoxin (I-131), and a geochemical tracer (I-129). But the cycling of iodine through terrestrial ecosystems...
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