个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共77条记录   Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA [作者：Mei, Y; Wang, ZX; Zhang, L; Zhang, YR; Li, XY; Liu, HH; Ye, J; You, H,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4898-4903 , 文章类型： Article，,卷期：2012年109-13] Neuroblastoma is a common childhood malignant tumor originated from the neural crest-derived sympathetic nervous system. A crucial early event in neuroblastoma pathogenesis is arrested differentiation of neuroblasts at v... Mitochondrial pathway of apoptosis is ancestral in metazoans [作者：Bender, CE; Fitzgerald, P; Tait, SWG; Llambi, F; McStay, GP; Tupper, DO; Pellettieri, J; Alvarado, AS; Salvesen, GS; Green, DR,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4904-4909 , 文章类型： Article，,卷期：2012年109-13] The mitochondrial pathway of apoptosis is the major mechanism of physiological cell death in vertebrates. In this pathway, proapoptotic members of the Bcl-2 family cause mitochondrial outer membrane permeabilization (MOM... Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma [作者：Xu, X; Rock, JR; Lu, Y; Futtner, C; Schwab, B; Guinney, J; Hogan, BLM; Onaitis, MW,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4910-4915 , 文章类型： Article，,卷期：2012年109-13] Identifying the cells of origin of lung cancer may lead to new therapeutic strategies. Previous work has focused upon the putative bronchoalveolar stem cell at the bronchioalveolar duct junction as a cancer cell of origi... Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform [作者：Lee, SS; Vizcarra, IA; Huberts, DHEW; Lee, LP; Heinemann, M,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4916-4920 , 文章类型： Article，,卷期：2012年109-13] Important insights into aging have been generated with the genetically tractable and short-lived budding yeast. However, it is still impossible today to continuously track cells by high-resolution microscopic imaging (e.... Divergent role of the Hox gene Antennapedia in spiders is responsible for the convergent evolution of abdominal limb repression [作者：Khadjeh, S; Turetzek, N; Pechmann, M; Schwager, EE; Wimmer, EA; Damen, WGM; Prpic, NM,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4921-4926 , 文章类型： Article，,卷期：2012年109-13] Evolution often results in morphologically similar solutions in different organisms, a phenomenon known as convergence. However, there is little knowledge of the processes that lead to convergence at the genetic level. T... Permian vegetational Pompeii from Inner Mongolia and its implications for landscape paleoecology and paleobiogeography of Cathaysia [作者：Wang, J; Pfefferkorn, HW; Zhang, Y; Feng, Z,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4927-4932 , 文章类型： Article，,卷期：2012年109-13] Plant communities of the geologic past can be reconstructed with high fidelity only if they were preserved in place in an instant in time. Here we report such a flora from an early Permian (ca. 298 Ma) ash-fall tuff in I... Oil sands mining and reclamation cause massive loss of peatland and stored carbon [作者：Rooney, RC; Bayley, SE; Schindler, DW,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4933-4937 , 文章类型： Article，,卷期：2012年109-13] We quantified the wholesale transformation of the boreal landscape by open-pit oil sands mining in Alberta, Canada to evaluate its effect on carbon storage and sequestration. Contrary to claims made in the media, peatlan... Continent-wide risk assessment for the establishment of nonindigenous species in Antarctica [作者：Chown, SL; Huiskes, AHL; Gremmen, NJM; Lee, JE; Terauds, A; Crosbie, K; Frenot, Y; Hughes, KA; Imura, S; Kiefer, K; Lebouvier, M; Raymond, B; Tsujimoto, M; Ware, C; Van de Vijver, B; Bergstrom, DM,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4938-4943 , 文章类型： Article，,卷期：2012年109-13] Invasive alien species are among the primary causes of biodiversity change globally, with the risks thereof broadly understood for most regions of the world. They are similarly thought to be among the most significant co... Nanoalumina promotes the horizontal transfer of multiresistance genes mediated by plasmids across genera [作者：Qiu, ZG; Yu, YM; Chen, ZL; Jin, M; Yang, D; Zhao, ZG; Wang, JF; Shen, ZQ; Wang, XW; Qian, D; Huang, AH; Zhang, BC; Li, JW,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4944-4949 , 文章类型： Article，,卷期：2012年109-13] Antibiotic resistance is a worldwide public health concern. Conjugative transfer between closely related strains or species of bacteria is an important method for the horizontal transfer of multidrug-resistance genes. Th... Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations [作者：Good, BH; Rouzine, IM; Balick, DJ; Hallatschek, O; Desai, MM,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4950-4955 , 文章类型： Article，,卷期：2012年109-13] When large asexual populations adapt, competition between simultaneously segregating mutations slows the rate of adaptation and restricts the set of mutations that eventually fix. This phenomenon of interference arises f... Major taste loss in carnivorous mammals [作者：Jiang, PH; Josue, J; Li, X; Glaser, D; Li, WH; Brand, JG; Margolskee, RF; Reed, DR; Beauchamp, GK,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4956-4961 , 文章类型： Article，,卷期：2012年109-13] Mammalian sweet taste is primarily mediated by the type 1 taste receptor Tas1r2/Tas1r3, whereas Tas1r1/Tas1r3 act as the principal umami taste receptor. Bitter taste is mediated by a different group of G protein-coupled ... Lateral gene transfer as a support for the tree of life [作者：Abby, SS; Tannier, E; Gouy, M; Daubin, V,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4962-4967 , 文章类型： Article，,卷期：2012年109-13] Lateral gene transfer (LGT), the acquisition of genes from other species, is a major evolutionary force. However, its success as an adaptive process makes the reconstruction of the history of life an intricate puzzle: If... DNA methylation dynamics, metabolic fluxes, gene splicing, and alternative phenotypes in honey bees [作者：Foret, S; Kucharski, R; Pellegrini, M; Feng, SH; Jacobsen, SE; Robinson, GE; Maleszka, R,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4968-4973 , 文章类型： Article，,卷期：2012年109-13] In honey bees (Apis mellifera), the development of a larva into either a queen or worker depends on differential feeding with royal jelly and involves epigenomic modifications by DNA methyltransferases. To understand the... Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk [作者：Fu, YP; Kohaar, I; Rothman, N; Earl, J; Figueroa, JD; Ye, Y; Malats, N; Tang, W; Liu, L; Garcia-Closas, M; Muchmore, B; Chatterjee, N; Tarway, M; Kogevinas, M; Porter-Gill, P; Baris, D; Mumy, A; Albanes, D; Purdue, MP; Hutchinson, A; Carrato, A; Tardon, A; Serra, C; Garcia-Closas, R; Lloreta, J; Johnson, A; Schwenn, M; Karagas, MR; Schned, A; Diver, WR; Gapstur, SM; Thun, MJ; Virtamo, J; Chanock, SJ; Fraumeni, JF; Silverman, DT; Wu, XF; Real, FX; Prokunina-Olsson, L,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4974-4979 , 文章类型： Article，,卷期：2012年109-13] Genome-wide association studies have identified a SNP, rs2294008, on 8q24.3 within the prostate stem cell antigen (PSCA) gene, as a risk factor for bladder cancer. To fine-map this region, we imputed 642 SNPs within 100 ... Mutation in a primate-conserved retrotransposon reveals a noncoding RNA as a mediator of infantile encephalopathy [作者：Cartault, F; Munier, P; Benko, E; Desguerre, I; Hanein, S; Boddaert, N; Bandiera, S; Vellayoudom, J; Krejbich-Trotot, P; Bintner, M; Hoarau, JJ; Girard, M; Genin, E; de Lonlay, P; Fourmaintraux, A; Naville, M; Rodriguez, D; Feingold, J; Renouil, M; Munnich, A; Westhof, E; Fahling, M; Lyonnet, S; Henrion-Caude, A,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4980-4985 , 文章类型： Article，,卷期：2012年109-13] The human genome is densely populated with transposons and transposon-like repetitive elements. Although the impact of these transposons and elements on human genome evolution is recognized, the significance of subtle va... Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis [作者：Bras, S; Martin-Lanneree, S; Gobert, V; Auge, B; Breig, O; Sanial, M; Yamaguchi, M; Haenlin, M; Plessis, A; Waltzer, L,期刊：Proceedings of the National Academy of Sciences of the United States of America, 页码：4986-4991 , 文章类型： Article，,卷期：2012年109-13] Defining the function of the genes that, like RUNX1, are deregulated in blood cell malignancies represents an important challenge. Myeloid leukemia factors (MLFs) constitute a poorly characterized family of conserved pro...